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Clinical data | |
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Trade names | Zinecard, Cardioxane, others |
Other names | Dexrazoxane hydrochloride |
AHFS/Drugs.com | Monograph |
MedlinePlus | a609010 |
License data |
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Routes of administration | Intravenous |
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Identifiers | |
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Chemical and physical data | |
Formula | C11H16N4O4 |
Molar mass | 268.273 g·mol−1 |
3D model (JSmol) | |
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Dexrazoxane, sold under the brand name Zinecard among others, is a medication used to prevent cardiomyopathy due to doxorubicin and in extravasation of anthracyclines.[1][2] It is given by injection into a vein.[1]
Common side effects include pain at the site of injection, nausea, and diarrhea.[3][1] Other side effects may include bone marrow suppression.[3] In children in may increase the risk of further cancers.[4] It is an antidote to anthracyclines.[2]
Dexrazoxane was discovered in 1972.[4] It was approved for medical use in the United States in 1995 and Europe in 2006.[1][2] In the United States 500 mg costs about 420 USD as of 2021.[5] This amount in the United Kingdom is about £160.[6]
References
edit- ^ a b c d e "Dexrazoxane Monograph for Professionals". Drugs.com. Archived from the original on 8 May 2021. Retrieved 23 December 2021.
- ^ a b c d "Savene". Archived from the original on 12 November 2020. Retrieved 23 December 2021.
- ^ a b c "DailyMed - DEXRAZOXANE- dexrazoxane for injection injection, powder, lyophilized, for solution". dailymed.nlm.nih.gov. Archived from the original on 26 March 2021. Retrieved 23 December 2021.
- ^ a b Kim, Kyu-Won; Roh, Jae Kyung; Wee, Hee-Jun; Kim, Chan (14 November 2016). Cancer Drug Discovery: Science and History. Springer. p. 250. ISBN 978-94-024-0844-7. Archived from the original on 11 January 2022. Retrieved 23 December 2021.
- ^ "Dexrazoxane Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 22 April 2021. Retrieved 23 December 2021.
- ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 984. ISBN 978-0857114105.