User:GAThrawn22/Sandbox/protboxtest2

Insulin

Insulin hexamers

Gene code: HUGO code:INS
Gene type: Protein coding
Molecular Weight: 11982 (Da)
Structure: Solution Structure of Human pro-Insulin Polypeptide
Protein type: insulin family
Functions: glucose regulation
Domains: INS
Motifs: SP
Diseases: familial hyperproinsulinemia
Pharmaceuticals: Humulin, Humalog (Eli Lilly) and Novolin(Novo Nordisk)
Taxa expressing: Homo sapiens; homologs: many metazoan taxa
Cell types: pancreas
Subcellular localization: extracellular
Covalent modifications: glycation, proteolytic cleavage
Other names: proinsulin


2-oxoglutarate dehydrogenase E1 component (α-Ketoglutarate dehydrogenase)
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Gene code: HUGO code:OGDH
Gene type: protein coding
Molecular Weight: 115942 (Da)
Protein type: Enzyme: Dehyrogenase
Functions: converts alpha ketoglutarate to succinyl CoA
Catalytic activity: 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2)
Cofactor(s): Thiamine pyrophosphate
Enzyme Regulation: Catabolite repressed
Diseases: Alpha-Ketoglutarate Dehydrogenase Deficiency
Taxa expressing: Homo sapiens; homologs: ubiquitous among oxidatively respiring organisms
Cell types: ubiquitous among aerobic cells
Subcellular localization: mitochondrion
Other names: Alpha-ketoglutarate dehydrogenase
Pathway(s): Citric acid cycle, Lysine degradation
Symbol(s): CF
Entrez: 1431
OMIM: 118950
RefSeq: NM_004077
UniProt: O75390
EC number: 4.1.3.7
Locus: Chr. 12 p11-qter