Southpaw is another name for a left-handed individual, particularly in sports. Southpaw may also refer to:

Arts and entertainment

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Music

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Sports

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Other

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  • Southpaw Technology, an open-source software company
  • Southpaw engine, a video game engine for the Game Boy Advance
  • Southpaw, a NODAL-related gene involved in left-right body patterning in vertebrates