Double-stranded RNA-binding protein Staufen homolog 2 is a protein that in humans is encoded by the STAU2 gene.[5][6]

STAU2
Identifiers
AliasesSTAU2, 39K2, 39K3, staufen double-stranded RNA binding protein 2
External IDsOMIM: 605920; MGI: 1352508; HomoloGene: 8666; GeneCards: STAU2; OMA:STAU2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001111272
NM_025303
NM_001347044
NM_001347045

RefSeq (protein)

NP_001104742
NP_001333973
NP_001333974
NP_079579

Location (UCSC)Chr 8: 73.42 – 73.75 MbChr 1: 16.3 – 16.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events.[6] Expression of Stau2 was sufficient to increase eye size, suggesting a novel biological role of Stau2 in eye morphogenesis.[7] Acting as a HIV-1 dependency factor, Staufen-2 promotes HIV-1 proliferation by positively regulating RNA export activity of viral protein Rev [8] and recently it was reported that Staufen-2 is incorporated into HIV-1 particles and boost viral infectivity[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000040341Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025920Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Buchner G, Bassi MT, Andolfi G, Ballabio A, Franco B (November 1999). "Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region". Genomics. 62 (1): 113–8. doi:10.1006/geno.1999.6015. PMID 10585778.
  6. ^ a b "Entrez Gene: STAU2 staufen, RNA binding protein, homolog 2 (Drosophila)".
  7. ^ Cockburn, Diane M.; Charish, Jason; Tassew, Nardos G.; Eubanks, James; Bremner, Rod; Macchi, Paolo; Monnier, Philippe P. (November 2012). "The double-stranded RNA-binding protein Staufen 2 regulates eye size". Molecular and Cellular Neuroscience. 51 (3–4): 101–111. doi:10.1016/j.mcn.2012.08.008. PMID 22940085. S2CID 5193038.
  8. ^ Banerjee, Atoshi; Benjamin, Ronald; Balakrishnan, Kannan; Ghosh, Payel; Banerjee, Sharmistha (2014-02-13). "Human protein Staufen-2 promotes HIV-1 proliferation by positively regulating RNA export activity of viral protein Rev". Retrovirology. 11: 18. doi:10.1186/1742-4690-11-18. ISSN 1742-4690. PMC 4016256. PMID 24520823.
  9. ^ Balakrishnan, Kannan; Jaguva Vasudevan, Ananda; Mohareer, Krishnaveni; Luedde, Tom; Münk, Carsten; Banerjee, Sharmistha (2021-12-08). "Encapsidation of Staufen-2 Enhances Infectivity of HIV-1". Viruses. 13 (12): 2459. doi:10.3390/v13122459. ISSN 1999-4915. PMC 8703407. PMID 34960728.

Further reading

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