SP110 nuclear body protein is a protein that in humans is encoded by the SP110 gene.[4][5][6]

SP110
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesSP110, IFI41, IFI75, IPR1, VODI, SP110 nuclear body protein
External IDsOMIM: 604457; MGI: 3783243; HomoloGene: 82192; GeneCards: SP110; OMA:SP110 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr 2: 230.17 – 230.23 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135899Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Kadereit S, Gewert DR, Galabru J, Hovanessian AG, Meurs EF (Dec 1993). "Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins". J Biol Chem. 268 (32): 24432–41. doi:10.1016/S0021-9258(20)80544-4. PMID 7693701.
  5. ^ Welsh GI, Kadereit S, Coccia EM, Hovanessian AG, Meurs EF (Aug 1999). "Colocalization within the nucleolus of two highly related IFN-induced human nuclear phosphoproteins with nucleolin". Exp Cell Res. 250 (1): 62–74. doi:10.1006/excr.1999.4505. PMID 10388521.
  6. ^ a b "Entrez Gene: SP110 SP110 nuclear body protein".
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Further reading

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