Serine/arginine-rich splicing factor 7 (SRSF7) also known as splicing factor, arginine/serine-rich 7 (SFRS7) or splicing factor 9G8 is a protein that in humans is encoded by the SRSF7 gene.[5]

SRSF7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSRSF7, 9G8, AAG3, SFRS7, serine/arginine-rich splicing factor 7, serine and arginine rich splicing factor 7
External IDsOMIM: 600572; MGI: 1926232; HomoloGene: 134446; GeneCards: SRSF7; OMA:SRSF7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001031684
NM_001195446
NM_006276
NM_001363802

NM_001195485
NM_001195486
NM_001195487
NM_146083
NM_001360435

RefSeq (protein)

NP_001026854
NP_001182375
NP_001350731

NP_001182414
NP_001182415
NP_001182416
NP_666195
NP_001347364

Location (UCSC)Chr 2: 38.74 – 38.75 MbChr 17: 80.51 – 80.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115875Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024097Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: SFRS7 splicing factor, arginine/serine-rich 7, 35kDa".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.