Secreted frizzled-related protein 2 is a protein that in humans is encoded by the SFRP2 gene.[5][6] This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.[6]

SFRP2
Identifiers
AliasesSFRP2, FRP-2, SARP1, SDF-5, secreted frizzled related protein 2
External IDsOMIM: 604157; MGI: 108078; HomoloGene: 56438; GeneCards: SFRP2; OMA:SFRP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003013

NM_009144

RefSeq (protein)

NP_003004

NP_033170

Location (UCSC)Chr 4: 153.78 – 153.79 MbChr 3: 83.67 – 83.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

New cardiomyocytes can be regenerated in the mouse heart via Sfrp2 and this may lead to treatment of heart injury [1].

Cancer

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SFRP2 gene has been detected progressively overexpressed in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.[7] For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145423Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027996Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Melkonyan HS, Chang WC, Shapiro JP, Mahadevappa M, Fitzpatrick PA, Kiefer MC, Tomei LD, Umansky SR (Jan 1998). "SARPs: A family of secreted apoptosis-related proteins". Proc Natl Acad Sci U S A. 94 (25): 13636–41. doi:10.1073/pnas.94.25.13636. PMC 28358. PMID 9391078.
  6. ^ a b "Entrez Gene: SFRP2 secreted frizzled-related protein 2".
  7. ^ a b Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. hdl:11392/2066612. PMID 25205602. S2CID 24986454.

Further reading

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