Robert Lewis Letsinger (July 31, 1921 – May 26, 2014) was an American biochemist and was a professor of chemistry at Northwestern University. He was best known for his research and development of chemical synthesis of DNA.[1]

Robert L. Letsinger
Born(1921-07-31)July 31, 1921
DiedMay 26, 2014(2014-05-26) (aged 92)
NationalityAmerican
Alma materMassachusetts Institute of Technology
Known forDNA Synthesis
Scientific career
FieldsBiochemistry
InstitutionsNorthwestern University
Doctoral advisorAvery Morton
Doctoral studentsMarvin H. Caruthers, Kelvin Ogilvie

Life

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Letsinger earned his B.S. in 1943 his Ph.D. in 1945, both at the Massachusetts Institute of Technology in Cambridge, Massachusetts. In 1946, he joined the department of chemistry at Northwestern University. He retired from teaching in 1991 as the emeritus Clare Hamilton Hall Professor.

Work

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In the 1960s, Letsinger developed methods for solid phase synthesis of oligonucleotides, including the phosphoric triester method[2] and the phosphoramidite synthesis. He thus laid the foundations for efficient automated synthesis of gene fragments and thus the rapid development of molecular biology.[3]

Letsingers later dealt with nanotechnology and its application in DNA diagnostics. In 2000, Letsinger was one of the founders of the biotechnology company Nanosphere Inc.

Awards

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Personal life

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Letsinger was married to Dorothy Thompson (1922-2010) in 1943. The couple had three children.[1]

References

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  1. ^ a b Fellman, Megan (6 June 2014). "Pioneer in DNA Synthesis Dies at Age 92: Northwestern University News". www.northwestern.edu. Northwestern News. Retrieved 12 September 2016.
  2. ^ Letsinger, Robert L.; Ogilvie, Kelvin K. (June 1969). "Nucleotide chemistry. XIII. Synthesis of oligothymidylates via phosphotriester intermediates". Journal of the American Chemical Society. 91 (12): 3350–3355. doi:10.1021/ja01040a042.
  3. ^ Caruthers, Marvin H. (23 December 2014). "Robert Letsinger: The father of synthetic DNA chemistry". Proceedings of the National Academy of Sciences. 111 (51): 18098–18099. Bibcode:2014PNAS..11118098C. doi:10.1073/pnas.1420277111. PMC 4280628. PMID 25422449.
  4. ^ "Robert L. Letsinger". John Simon Guggenheim Memorial Foundation. Retrieved September 12, 2016.
  5. ^ "Robert L. Letsinger". National Academy of Sciences. Retrieved September 12, 2016.
  6. ^ "Book of Members, 1780–2010: Chapter L" (PDF). American Academy of Arts and Sciences. Retrieved September 12, 2016.