RNA-binding protein with serine-rich domain 1 is a protein that in humans is encoded by the RNPS1 gene.[5][6][7]

RNPS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRNPS1, E5.1, RNA binding protein with serine rich domain 1
External IDsOMIM: 606447; MGI: 97960; HomoloGene: 40648; GeneCards: RNPS1; OMA:RNPS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001286625
NM_001286626
NM_001286627
NM_006711
NM_080594

NM_001080127
NM_001080128
NM_009070
NM_001357626

RefSeq (protein)

NP_001273554
NP_001273555
NP_001273556
NP_006702
NP_542161

NP_001073596
NP_001073597
NP_033096
NP_001344555

Location (UCSC)Chr 16: 2.25 – 2.27 MbChr 17: 24.63 – 24.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Two splice variants have been found for this gene; both variants encode the same protein.[7]

Interactions

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RNPS1 has been shown to interact with SART3[8] and Pinin.[9][10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000205937Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034681Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Loyer P, Trembley JH, Lahti JM, Kidd VJ (Jun 1998). "The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinase in vivo". Journal of Cell Science. 111 ( Pt 11) (11): 1495–506. doi:10.1242/jcs.111.11.1495. PMID 9580558.
  6. ^ Badolato J, Gardiner E, Morrison N, Eisman J (Dec 1995). "Identification and characterisation of a novel human RNA-binding protein". Gene. 166 (2): 323–7. doi:10.1016/0378-1119(95)00571-4. PMID 8543184.
  7. ^ a b "Entrez Gene: RNPS1 RNA binding protein S1, serine-rich domain".
  8. ^ Harada K, Yamada A, Yang D, Itoh K, Shichijo S (Sep 2001). "Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation". International Journal of Cancer. 93 (5): 623–8. doi:10.1002/ijc.1391. PMID 11477570. S2CID 24724555.
  9. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  10. ^ Li C, Lin RI, Lai MC, Ouyang P, Tarn WY (Oct 2003). "Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1". Molecular and Cellular Biology. 23 (20): 7363–76. doi:10.1128/MCB.23.20.7363-7376.2003. PMC 230327. PMID 14517304.

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: Q15287 (RNA-binding protein with serine-rich domain 1) at the PDBe-KB.