Tyrosine-protein kinase-like 7 also known as colon carcinoma kinase 4 (CCK4) is a receptor tyrosine kinase that in humans is encoded by the PTK7 gene.[5][6]

PTK7
Identifiers
AliasesPTK7, CCK-4, CCK4, protein tyrosine kinase 7 (inactive)
External IDsOMIM: 601890; MGI: 1918711; HomoloGene: 43672; GeneCards: PTK7; OMA:PTK7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_175168

RefSeq (protein)

NP_001257327
NP_002812
NP_690619
NP_690620
NP_690621

NP_780377

Location (UCSC)Chr 6: 43.08 – 43.16 MbChr 17: 46.88 – 46.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene an intracellular domain with tyrosine kinase homology and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene.[6]

PTK7 serves as a context-dependent signalling switch for the Wnt pathways (particularly in planar cell polarity related functions such as convergent extension and neural crest cell migration) and appears to have similar functions for plexin and Flt-1 pathways.[7] PTK7 was identified to be highly expressed in colon cancer by Saha et al. using serial analysis of gene expression (LongSAGE).[8] Pfizer is targeting PTK7 for cancer by generating an antibody-drug conjugate against the PTK7 receptor.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112655Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023972Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mossie K, Jallal B, Alves F, Sures I, Plowman GD, Ullrich A (Nov 1995). "Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family". Oncogene. 11 (10): 2179–84. PMID 7478540.
  6. ^ a b "Entrez Gene: PTK7 PTK7 protein tyrosine kinase 7".
  7. ^ Peradziryi H, Tolwinski NS, Borchers A (Aug 2012). "The many roles of PTK7: a versatile regulator of cell-cell communication". Archives of Biochemistry and Biophysics. 524 (1): 71–6. doi:10.1016/j.abb.2011.12.019. PMID 22230326.
  8. ^ Saha, S., et al. (2002). "Using the transcriptome to annotate the genome." Nat Biotechnol 20(5): 508-512.

Further reading

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