Nupapillomavirus is a genus of viruses in the family Papillomaviridae.[1] Humans serve as natural hosts. There is only one species in this genus: Nupapillomavirus 1. Diseases associated with this genus include facial warts. This virus has also been detected in some skin carcinomas and premalignant keratoses.[2][3]

Nupapillomavirus
Virus classification Edit this classification
(unranked): Virus
Realm: Monodnaviria
Kingdom: Shotokuvirae
Phylum: Cossaviricota
Class: Papovaviricetes
Order: Zurhausenvirales
Family: Papillomaviridae
Genus: Nupapillomavirus

Structure

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Viruses in Nupapillomavirus are non-enveloped, with icosahedral geometries, and T=7 symmetry. The diameter is around 52-55 nm. Genomes are circular, around 8kb in length.[2]

Genus Structure Symmetry Capsid Genomic arrangement Genomic segmentation
Nupapillomavirus Icosahedral T=7 Non-enveloped Circular Monopartite

Life cycle

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Viral replication is nuclear. Entry into the host cell is achieved by attachment of the viral proteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. DNA-templated transcription, with some alternative splicing mechanism is the method of transcription. The virus exits the host cell by nuclear envelope breakdown. Human serve as the natural host. Transmission routes are contact.[2]

Genus Host details Tissue tropism Entry details Release details Replication site Assembly site Transmission
Nupapillomavirus Humans Epithelial: mucous; epithelial: skin Cell receptor endocytosis Lysis Nucleus Nucleus Contact

References

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  1. ^ Van Doorslaer, K; Chen, Z; Bernard, HU; Chan, PKS; DeSalle, R; Dillner, J; Forslund, O; Haga, T; McBride, AA; Villa, LL; Burk, RD; ICTV Report Consortium (August 2018). "ICTV Virus Taxonomy Profile: Papillomaviridae". The Journal of General Virology. 99 (8): 989–990. doi:10.1099/jgv.0.001105. PMC 6171710. PMID 29927370.
  2. ^ a b c "Viral Zone". ExPASy. Retrieved 15 June 2015.
  3. ^ "Virus Taxonomy: 2020 Release". International Committee on Taxonomy of Viruses (ICTV). March 2021. Retrieved 10 May 2021.
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