Joe Louis (1914–1981) was an American world heavyweight boxing champion.
Joe Louis may also refer to:
- Sakorn Yang-keawsot (1922–2007), Thai dancer & puppeteer a.k.a. Joe Louis
- Joe Hill Louis (1921–1957), American musician
- Joe Louis Arena in Detroit
- Jos Louis, chocolate pastry
- Joe Louis (horse), a horse owned by the United States Army