Immunoglobulin lambda-like polypeptide 1 is a protein that in humans is encoded by the IGLL1 gene.[5][6][7] IGLL1 has also recently been designated CD179B (cluster of differentiation 179B).

IGLL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIGLL1, 14.1, AGM2, CD179b, IGL1, IGL5, IGLJ14.1, IGLL, IGO, IGVPB, VPREB2, immunoglobulin lambda like polypeptide 1
External IDsOMIM: 146770; MGI: 96529; HomoloGene: 131669; GeneCards: IGLL1; OMA:IGLL1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020070
NM_152855
NM_001369906

NM_001190325

RefSeq (protein)

NP_064455
NP_690594
NP_001356835

NP_001177254

Location (UCSC)Chr 22: 23.57 – 23.58 MbChr 16: 16.68 – 16.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

It is associated with agammaglobulinemia-2.

The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128322Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000075370Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bauer SR, Huebner K, Budarf M, Finan J, Erikson J, Emanuel BS, Nowell PC, Croce CM, Melchers F (Nov 1988). "The human Vpre B gene is located on chromosome 22 near a cluster of V lambda gene segments". Immunogenetics. 28 (5): 328–33. doi:10.1007/BF00364231. PMID 3139558. S2CID 6981867.
  6. ^ Schiff C, Milili M, Fougereau M (Dec 1989). "Isolation of early immunoglobulin lambda-like gene transcripts in human fetal liver". Eur J Immunol. 19 (10): 1873–8. doi:10.1002/eji.1830191018. PMID 2511029. S2CID 84544002.
  7. ^ a b "Entrez Gene: IGLL1 immunoglobulin lambda-like polypeptide 1".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.