Hygromycin B 4-O-kinase

Hygromycin B 4-O-kinase (EC 2.7.1.163, hygromycin-B kinase) is an enzyme with systematic name ATP:hygromycin-B 4-O-phosphotransferase.[1] This enzyme catalyses the following chemical reaction

Hygromycin B 4-O-kinase
Identifiers
EC no.2.7.1.163
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins
ATP + hygromycin B ADP + 4-O-phosphohygromycin B

Phosphorylates the antibiotic hygromycin B.

References

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  1. ^ Rao RN, Allen NE, Hobbs JN, Alborn WE, Kirst HA, Paschal JW (November 1983). "Genetic and enzymatic basis of hygromycin B resistance in Escherichia coli". Antimicrobial Agents and Chemotherapy. 24 (5): 689–95. doi:10.1128/aac.24.5.689. PMC 185926. PMID 6318654.
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