Eukaryotic peptide chain release factor GTP-binding subunit ERF3A is an enzyme that in humans is encoded by the GSPT1 gene.[5][6][7]

GSPT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGSPT1, 551G9.2, ETF3A, GST1, eRF3a, G1 to S phase transition 1
External IDsOMIM: 139259; MGI: 1316728; HomoloGene: 68226; GeneCards: GSPT1; OMA:GSPT1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002094
NM_001130006
NM_001130007

NM_001130008
NM_146066

RefSeq (protein)

NP_001123478
NP_001123479
NP_002085

NP_001123480
NP_666178

Location (UCSC)Chr 16: 11.87 – 11.92 MbChr 16: 11.04 – 11.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

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GSPT1 has been shown to interact with BIRC2.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103342Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062203Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hoshino S, Miyazawa H, Enomoto T, Hanaoka F, Kikuchi Y, Kikuchi A, Ui M (Dec 1989). "A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells". The EMBO Journal. 8 (12): 3807–14. doi:10.1002/j.1460-2075.1989.tb08558.x. PMC 402068. PMID 2511002.
  6. ^ Lee JA, Park JE, Lee DH, Park SG, Myung PK, Park BC, Cho S (Feb 2008). "G1 to S phase transition protein 1 induces apoptosis signal-regulating kinase 1 activation by dissociating 14-3-3 from ASK1". Oncogene. 27 (9): 1297–305. doi:10.1038/sj.onc.1210740. PMID 17700517.
  7. ^ "Entrez Gene: GSPT1 G1 to S phase transition 1".
  8. ^ Hegde R, Srinivasula SM, Datta P, Madesh M, Wassell R, Zhang Z, Cheong N, Nejmeh J, Fernandes-Alnemri T, Hoshino S, Alnemri ES (Oct 2003). "The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein". The Journal of Biological Chemistry. 278 (40): 38699–706. doi:10.1074/jbc.M303179200. PMID 12865429.

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: P15170 (Eukaryotic peptide chain release factor GTP-binding subunit ERF3A) at the PDBe-KB.