Gamma-aminobutyric acid B receptor, 1 (GABAB1), is a G-protein coupled receptor subunit encoded by the GABBR1 gene.

GABBR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGABBR1, GABABR1, GABBR1-3, GB1, GPRC3A, dJ271M21.1.1, dJ271M21.1.2, gamma-aminobutyric acid type B receptor subunit 1
External IDsOMIM: 603540; MGI: 1860139; HomoloGene: 1132; GeneCards: GABBR1; OMA:GABBR1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001470
NM_021903
NM_021904
NM_021905
NM_001319053

NM_019439

RefSeq (protein)

NP_001305982
NP_001461
NP_068703
NP_068704

NP_062312

Location (UCSC)Chr 6: 29.56 – 29.63 MbChr 17: 37.36 – 37.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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GABAB1 is a receptor for Gamma-aminobutyric acid. Upon binding, GABAB1 will produce a slow and prolonged inhibitory effect. GABAB1 is one part of a heterodimer, which is the GABAB receptor, consisting of it and the related GABAB2 protein. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.[5]

Interactions

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GABBR1 has been shown to interact with ATF4[6] and GABBR2.[7]

See also

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References

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  1. ^ a b c ENSG00000206511, ENSG00000206466, ENSG00000232632, ENSG00000232569, ENSG00000237051, ENSG00000204681 GRCh38: Ensembl release 89: ENSG00000237112, ENSG00000206511, ENSG00000206466, ENSG00000232632, ENSG00000232569, ENSG00000237051, ENSG00000204681Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024462Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1".
  6. ^ White JH, McIllhinney RA, Wise A, Ciruela F, Chan WY, Emson PC, Billinton A, Marshall FH (December 2000). "The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13967–72. Bibcode:2000PNAS...9713967W. doi:10.1073/pnas.240452197. PMC 17684. PMID 11087824.
  7. ^ White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH (December 1998). "Heterodimerization is required for the formation of a functional GABA(B) receptor". Nature. 396 (6712): 679–82. Bibcode:1998Natur.396..679W. doi:10.1038/25354. PMID 9872316. S2CID 4406311.

Further reading

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  • "GABAB Receptors: GABAB1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-04.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.