Frizzled-10 (Fz-10) is a protein that in humans is encoded by the FZD10 gene.[5][6] Fz-10 has also been designated as CD350 (cluster of differentiation 350).

FZD10
Identifiers
AliasesFZD10, CD350, FZ-10, Fz10, FzE7, hFz10, frizzled class receptor 10
External IDsOMIM: 606147; MGI: 2136761; HomoloGene: 21411; GeneCards: FZD10; OMA:FZD10 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007197

NM_175284

RefSeq (protein)

NP_009128

NP_780493

Location (UCSC)Chr 12: 130.16 – 130.17 MbChr 5: 128.68 – 128.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111432Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000081683Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Koike J, Takagi A, Miwa T, Hirai M, Terada M, Katoh M (Aug 1999). "Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family". Biochemical and Biophysical Research Communications. 262 (1): 39–43. doi:10.1006/bbrc.1999.1161. PMID 10448064.
  6. ^ a b "Entrez Gene: FZD10 frizzled homolog 10 (Drosophila)".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.