Farnesyl-diphosphate farnesyltransferase 1

Farnesyl-diphosphate farnesyltransferase 1 is a protein that in humans is encoded by the FDFT1 gene. [5]

FDFT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFDFT1, DGPT, ERG9, SQS, SS, farnesyl-diphosphate farnesyltransferase 1, SQSD
External IDsOMIM: 184420; MGI: 102706; HomoloGene: 3281; GeneCards: FDFT1; OMA:FDFT1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_010191
NM_001360211

RefSeq (protein)

NP_034321
NP_001347140

Location (UCSC)Chr 8: 11.8 – 11.84 MbChr 14: 63.38 – 63.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.

References

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  1. ^ a b c ENSG00000284967 GRCh38: Ensembl release 89: ENSG00000079459, ENSG00000284967Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021273Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Farnesyl-diphosphate farnesyltransferase 1". Retrieved 2016-06-25.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.