Ectonucleoside triphosphate diphosphohydrolase 4

Ectonucleoside triphosphate diphosphohydrolase 4 is a protein that in humans is encoded by the ENTPD4 gene. [5]

ENTPD4
Identifiers
AliasesENTPD4, LALP70, LAP70, LYSAL1, NTPDase-4, UDPase, ectonucleoside triphosphate diphosphohydrolase 4
External IDsOMIM: 607577; MGI: 5435040; HomoloGene: 68421; GeneCards: ENTPD4; OMA:ENTPD4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004901
NM_001128930

NM_001359159
NM_001359160

RefSeq (protein)

NP_001122402
NP_004892

NP_080450
NP_001347281

Location (UCSC)Chr 8: 23.39 – 23.46 MbChr 14: 69.79 – 69.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium ion-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and these isoforms may differ in divalent cation dependence and substrate specificity. [provided by RefSeq, Sep 2011].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197217Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022066Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Ectonucleoside triphosphate diphosphohydrolase 4". Retrieved 2018-03-21.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.