Epsin-1 is a protein that in humans is encoded by the EPN1 gene.[5][6][7]

EPN1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEPN1, epsin 1
External IDsOMIM: 607262; MGI: 1333763; HomoloGene: 32172; GeneCards: EPN1; OMA:EPN1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001130071
NM_001130072
NM_013333
NM_001321263

NM_001252454
NM_010147

RefSeq (protein)

NP_001123543
NP_001123544
NP_001308192
NP_037465

NP_001239383
NP_034277
NP_001359429

Location (UCSC)Chr 19: 55.68 – 55.71 MbChr 7: 5.08 – 5.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

EPN1 is an endocytic accessory protein that interacts with EPS15 (MIM 600051), the alpha subunit of the clathrin adaptor AP2 (AP2A1; MIM 601026), and clathrin (see MIM 118960), as well as with other accessory proteins for the endocytosis of clathrin-coated vesicles.[supplied by OMIM][7]

Interactions

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EPN1 has been shown to interact with REPS2,[6] AP2A2[5] and EPS15.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000063245Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035203Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (Sep 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature. 394 (6695): 793–7. Bibcode:1998Natur.394..793C. doi:10.1038/29555. PMID 9723620. S2CID 4430975.
  6. ^ a b Morinaka K, Koyama S, Nakashima S, Hinoi T, Okawa K, Iwamatsu A, Kikuchi A (Dec 1999). "Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis". Oncogene. 18 (43): 5915–22. doi:10.1038/sj.onc.1202974. PMID 10557078.
  7. ^ a b "Entrez Gene: EPN1 epsin 1".

Further reading

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