Receptor-binding cancer antigen expressed on SiSo cells is a protein that in humans is encoded by the EBAG9 gene.

EBAG9
Identifiers
AliasesEBAG9, EB9, PDAF, estrogen receptor binding site associated, antigen, 9, estrogen receptor binding site associated antigen 9
External IDsOMIM: 605772; MGI: 1859920; HomoloGene: 3107; GeneCards: EBAG9; OMA:EBAG9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198120
NM_001278938
NM_004215

NM_019480
NM_001357690
NM_001357691

RefSeq (protein)

NP_001265867
NP_004206
NP_936056

NP_062353
NP_001344619
NP_001344620

Location (UCSC)Chr 8: 109.54 – 109.57 MbChr 15: 44.48 – 44.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor which binds to the estrogen-responsive element (ERE) found in the 5'-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for this gene.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147654Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022339Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: EBAG9 estrogen receptor binding site associated, antigen, 9".

Further reading

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