Dihydropyrimidinase is an enzyme that in humans is encoded by the DPYS gene.[5][6]

DPYS
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDPYS, dihydropyrimidinase, DHP, DHPase
External IDsOMIM: 613326; MGI: 1928679; HomoloGene: 20359; GeneCards: DPYS; OMA:DPYS - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001385

NM_001164466
NM_022722

RefSeq (protein)

NP_001376

NP_001157938
NP_073559

Location (UCSC)Chr 8: 104.33 – 104.47 MbChr 15: 39.63 – 39.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.[6]

Interactive pathway map

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Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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|alt=Fluorouracil (5-FU) Activity edit]]
Fluorouracil (5-FU) Activity edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147647Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022304Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.
  6. ^ a b "Entrez Gene: DPYS dihydropyrimidinase".

Further reading

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