Doublecortin-like kinase protein 1 (DCLK1)[5][6][7][8] is an enzyme that in humans is encoded by the DCLK1 gene.[5][6][8] Its C-terminal domain in rats is expressed independently from an alternative transcript, cpg16, and can function alone as a serine/threonine protein kinase that is cyclic AMP dependent.[9][10]

DCLK1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDCLK1, CL1, CLICK1, DCAMKL1, DCDC3A, DCLK, doublecortin like kinase 1
External IDsOMIM: 604742; MGI: 1330861; HomoloGene: 130530; GeneCards: DCLK1; OMA:DCLK1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 13: 35.77 – 36.13 MbChr 3: 55.15 – 55.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DCLK1 expression is a marker for tuft cells, a type of chemosensory cell of the intestinal epithelium.[7][11]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133083Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027797Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Omori Y, Suzuki M, Ozaki K, Harada Y, Nakamura Y, Takahashi E, Fujiwara T (Oct 1998). "Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin". J Hum Genet. 43 (3): 169–77. doi:10.1007/s100380050063. PMID 9747029.
  6. ^ a b Sossey-Alaoui K, Srivastava AK (May 1999). "DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX)". Genomics. 56 (1): 121–6. doi:10.1006/geno.1998.5718. PMID 10036192.
  7. ^ a b Ding L, Weygant N, Ding C, Lai Y, Li H (2023). "DCLK1 and tuft cells: Immune-related functions and implications for cancer immunotherapy". Critical Reviews in Oncology and Hematology. 191. doi:10.1016/j.critrevonc.2023.104118. PMID 37660932. Art. No. 104118.
  8. ^ a b "Entrez Gene: DCAMKL1 doublecortin and CaM kinase-like 1". Gene. National Library of Medicine. 7 April 2024. Retrieved 30 May 2024.
  9. ^ Silverman MA, Benard O, Jaaro H, Rattner A, Citri Y, Seger R (1999). "CPG16, a novel protein serine/threonine kinase downstream of cAMP-dependent protein kinase". Journal of Biological Chemistry. 274 (5): 2631–2636. doi:10.1074/jbc.274.5.2631. PMID 9915791.
  10. ^ Lin PT, Gleeson JG, Corbo JC, et al. (2001). "DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization". J. Neurosci. 20 (24): 9152–61. doi:10.1523/JNEUROSCI.20-24-09152.2000. PMC 6773030. PMID 11124993.
  11. ^ Gerbe F, Legraverend C, Jay P (2012). "The intestinal epithelium tuft cells: specification and function". Cellular and Molecular Life Sciences. 69 (17): 2907–2917. doi:10.1007/s00018-012-0984-7. PMC 3417095. PMID 22527717.

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: O15075 (Serine/threonine-protein kinase DCLK1) at the PDBe-KB.