Corticosteroid side-chain-isomerase

In enzymology, a corticosteroid side-chain-isomerase (EC 5.3.1.21) is an enzyme that catalyzes the chemical reaction

corticosteroid side-chain-isomerase
Identifiers
EC no.5.3.1.21
CAS no.75139-73-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins
11-deoxycorticosterone 20-hydroxy-3-oxopregn-4-en-21-al

Hence, this enzyme has one substrate, 11-deoxycorticosterone, and one product, 20-hydroxy-3-oxopregn-4-en-21-al.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is 11-deoxycorticosterone aldose-ketose-isomerase.

References

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  • Martin KO, Oh SW, Lee HJ, Monder C (1977). "Studies on 21-3H-labeled corticosteroids: evidence for isomerization of the ketol side chain of 11-deoxycorticosterone by a hamster liver enzyme". Biochemistry. 16 (17): 3803–9. doi:10.1021/bi00636a013. PMID 901753.
  • Monder C, Martin KO, Bogumil J (1980). "Presence of epimerase activity in hamster liver corticosteroid side chain isomerase". J. Biol. Chem. 255 (15): 7192–8. PMID 7391077.