Coiled-Coil Domain Containing Protein – 25

The Coiled-Coil Domain Containing Protein – 25 (CCDC25) is a human protein whose function is not presently understood.

CCDC25
Identifiers
AliasesCCDC25, Coiled-Coil Domain Containing Protein – 25, coiled-coil domain containing 25
External IDsMGI: 1914429; HomoloGene: 6645; GeneCards: CCDC25; OMA:CCDC25 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001304529
NM_001304530
NM_001304532
NM_018246

NM_145944

RefSeq (protein)

NP_001291458
NP_001291459
NP_001291461
NP_060716

NP_666056

Location (UCSC)Chr 8: 27.73 – 27.77 MbChr 14: 66.07 – 66.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gene

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The gene encoding the CCDC25 protein is located at 8p21.1, on the short arm of human chromosome 8,[5] and is transcribed into an mRNA product approximately 3,583 nucleotides in length.

Protein

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General

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The protein is highly conserved among mammals as well as eukaryotes as diverse as Arabidopsis thaliana. CCDC25 is made up of a single polypeptide chain 208 amino acids in length and is expressed at a high level, nearly 4.2 times that of a normal human protein.[6] Its expression is nearly ubiquitous in human tissues with little indication that its expression level changes drastically in diseased tissues.[7] Despite currently lacking a well understood function, CCDC25 is predicted to localize to the nucleus[6] and was shown by a microarray experiment to be upregulated in Metaphase II oocytes.[8]

Interactions

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CCDC25 was shown by a yeast-two-hybrid assay to interact with Smad2, a latent transcription factor that is part of the TGF-β signaling pathway.[9] The protein is a predicted substrate of Casein Kinase 1, Casein Kinase 2, cGMP-dependent protein kinase, and the Insulin Receptor; all of which have well defined roles in cell signaling.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147419Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022035Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Gene - CCDC25".
  6. ^ a b "AceView - CCDC25".
  7. ^ "EST Profile - CCDC25".
  8. ^ "GEO Profiles - GDS3256 CCDC25".
  9. ^ "MINT - CCDC25".

Further reading

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