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Clinofibrate (INN) (trade name Lipoclin) is a fibrate and a derivative of Bisphenol Z.[1]
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Routes of administration | Oral |
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Formula | C28H36O6 |
Molar mass | 468.590 g·mol−1 |
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Synthesis
editThe reaction between cyclohexanone and phenol gives Bisphenol Z (3).[2] This is treated with chloroform and methyl ethyl ketone in the presence of base. The resulting Bargellini reaction gives clinofibrate.[3]
References
edit- ^ Takeuchi N, Kukita H, Kajiyama G, Fujiyama M, Ishikawa K, Miki H, Mishima T, Murata K, Asano T (April 1982). "Effect of clinofibrate, a new hypolipidemic agent, on biliary and serum lipids in patients with hyperlipidemia". Atherosclerosis. 42 (2–3): 129–39. doi:10.1016/0021-9150(82)90145-9. PMID 7073798.
- ^ Patil, L.S.; Suryawanshi, V.S.; Pawar, O.B.; Shinde, N.D. (2011). "An Improved, Highly Efficient Method for the Synthesis of Bisphenols". e-Journal of Chemistry. 8 (4): 2016–2019. doi:10.1155/2011/372673.
- ^ Y Nakamura, S Aono, K Agatsuma, Y Tanaka, U.S. patent 3,716,583 (1973 to Sumitomo Chemical Co).