Cysteine-rich protein 2 is a protein that in humans is encoded by the CRIP2 gene.[5][6][7][8]

CRIP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCRIP2, CRIP, CRP2, ESP1, cysteine rich protein 2
External IDsOMIM: 601183; MGI: 1915587; HomoloGene: 135666; GeneCards: CRIP2; OMA:CRIP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001270837
NM_001270841
NM_001312

NM_024223
NM_001347443

RefSeq (protein)

NP_001257766
NP_001257770
NP_001303

NP_001334372
NP_077185

Location (UCSC)Chr 14: 105.47 – 105.48 MbChr 12: 113.1 – 113.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CRIP2 and the closely related CRIP1 are cysteine-rich proteins containing two LIM domains. They are highly expressed during cardiovascular development and act to bridge serum response factor and GATA proteins and stimulate smooth muscle target genes.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182809Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006356Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tsui SK, Chan PP, Cheuk CW, Liew CC, Waye MM, Fung KP, Lee CY (Feb 1997). "A novel cDNA encoding for a LIM domain protein located at human chromosome 14q32 as a candidate for leukemic translocation". Biochem Mol Biol Int. 39 (4): 747–54. doi:10.1080/15216549600201831. PMID 8843343. S2CID 25981657.
  6. ^ Karim MA, Ohta K, Egashira M, Jinno Y, Niikawa N, Matsuda I, Indo Y (January 1996). "Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3". Genomics. 31 (2): 167–76. doi:10.1006/geno.1996.0028. PMID 8824798.
  7. ^ Huber A, Neuhuber WL, Klugbauer N, Ruth P, Allescher HD (Mar 2000). "Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle". J Biol Chem. 275 (8): 5504–11. doi:10.1074/jbc.275.8.5504. PMID 10681529.
  8. ^ "Entrez Gene: CRIP2 cysteine-rich protein 2".
  9. ^ Chang DF, Belaguli NS, Iyer D, Roberts WB, Wu SP, Dong XR, Marx JG, Moore MS, Beckerle MC, Majesky MW, Schwartz RJ (January 2003). "Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors". Dev. Cell. 4 (1): 107–18. doi:10.1016/S1534-5807(02)00396-9. PMID 12530967.
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Further reading

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