Carboxypeptidase A4 is an enzyme that in humans is encoded by the CPA4 gene.[4][5][6]

CPA4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCPA4, CPA3, carboxypeptidase A4
External IDsOMIM: 607635; MGI: 1919041; HomoloGene: 56753; GeneCards: CPA4; OMA:CPA4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016352
NM_001163446

NM_027926

RefSeq (protein)

NP_001156918
NP_057436

NP_082202

Location (UCSC)n/aChr 6: 30.57 – 30.59 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness.[6]

References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039070Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Huang H, Reed CP, Zhang JS, Shridhar V, Wang L, Smith DI (Jul 1999). "Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells". Cancer Res. 59 (12): 2981–8. PMID 10383164.
  5. ^ Hayashida S, Yamasaki K, Asada Y, Soeda E, Niikawa N, Kishino T (Aug 2000). "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32". Genomics. 66 (2): 221–5. doi:10.1006/geno.2000.6206. PMID 10860668.
  6. ^ a b "Entrez Gene: CPA4 carboxypeptidase A4".
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Further reading

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