CCR4-NOT transcription complex subunit 7 is a protein that in humans is encoded by the CNOT7 gene.[5][6][7][8] It is a subunit of the CCR4-Not deadenylase complex.

CNOT7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCNOT7, CAF1, Caf1a, hCAF-1, CAF-1, CCR4-NOT transcription complex subunit 7
External IDsOMIM: 604913; MGI: 1298230; HomoloGene: 49011; GeneCards: CNOT7; OMA:CNOT7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001271542
NM_001271543
NM_011135
NM_001361938
NM_001361939

RefSeq (protein)

NP_001258471
NP_001258472
NP_035265
NP_001348867
NP_001348868

Location (UCSC)Chr 8: 17.22 – 17.25 MbChr 8: 40.95 – 40.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms.[8]

Interactions

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CNOT7 has been shown to interact with:

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198791Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031601Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (March 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.
  6. ^ Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC (March 1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. Bibcode:1992Natur.355..632A. doi:10.1038/355632a0. PMID 1538749. S2CID 4234345.
  7. ^ Robin-Lespinasse Y, Sentis S, Kolytcheff C, Rostan MC, Corbo L, Le Romancer M (February 2007). "hCAF1, a new regulator of PRMT1-dependent arginine methylation". J. Cell Sci. 120 (Pt 4): 638–47. doi:10.1242/jcs.03357. PMID 17264152. S2CID 6592326.
  8. ^ a b "Entrez Gene: CNOT7 CCR4-NOT transcription complex, subunit 7".
  9. ^ Bogdan JA, Adams-Burton C, Pedicord DL, Sukovich DA, Benfield PA, Corjay MH, Stoltenborg JK, Dicker IB (December 1998). "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1". Biochem. J. 336 (2): 471–81. doi:10.1042/bj3360471. PMC 1219893. PMID 9820826.
  10. ^ Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, Corbo L (March 2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. 276 (13): 9640–8. doi:10.1074/jbc.M008201200. PMID 11136725.
  11. ^ a b Funakoshi Y, Doi Y, Hosoda N, Uchida N, Osawa M, Shimada I, Tsujimoto M, Suzuki T, Katada T, Hoshino S (December 2007). "Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases". Genes Dev. 21 (23): 3135–48. doi:10.1101/gad.1597707. PMC 2081979. PMID 18056425.
  12. ^ a b Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T (December 1999). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". Oncogene. 18 (52): 7432–41. doi:10.1038/sj.onc.1203193. PMID 10602502.

Further reading

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