AZD0328 is an experimental drug. It is a selective α7 nicotinic receptor agonist that enhances cortical dopamine release and improves learning and attentional processes in rats.[1]

AZD0328
Legal status
Legal status
  • Investigational
Identifiers
  • 3H-4-Azaspiro[bicyclo[2.2.2]octane-2,2'-furo[2,3-b]pyridine]
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H16N2O
Molar mass216.284 g·mol−1
3D model (JSmol)
  • C1C2=CC=CN=C2OC11CN2CCC1CC2
  • InChI=1S/C13H16N2O/c1-2-10-8-13(16-12(10)14-5-1)9-15-6-3-11(13)4-7-15/h1-2,5,11H,3-4,6-9H2/t13-/m0/s1 checkY
  • Key:OCKIPDMKGPYYJS-ZDUSSCGKSA-N checkY
 ☒NcheckY (what is this?)  (verify)

References

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  1. ^ Sydserff S, Sutton EJ, Song D, Quirk MC, Maciag C, Li C, et al. (October 2009). "Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes". Biochemical Pharmacology. 78 (7): 880–8. doi:10.1016/j.bcp.2009.07.005. PMID 19615981.