Glutamate dehydrogenase 2, mitochondrial, also known as GDH 2, is an enzyme that in humans is encoded by the GLUD2 gene.[3][4][5] This dehydrogenase is one of the family of glutamate dehydrogenases that are ubiquitous in life.

GLUD2
Identifiers
AliasesGLUD2, GDH2, GLUDP1, glutamate dehydrogenase 2
External IDsOMIM: 300144; HomoloGene: 115647; GeneCards: GLUD2; OMA:GLUD2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012084

n/a

RefSeq (protein)

NP_036216

n/a

Location (UCSC)Chr X: 121.05 – 121.05 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

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Glutamate dehydrogenase 2 is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate.[3]

References

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  1. ^ a b c ENSG00000288118 GRCh38: Ensembl release 89: ENSG00000182890, ENSG00000288118Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: glutamate dehydrogenase 2".
  4. ^ Shashidharan P, Michaelidis TM, Robakis NK, Kresovali A, Papamatheakis J, Plaitakis A (June 1994). "Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene". J. Biol. Chem. 269 (24): 16971–6. doi:10.1016/S0021-9258(19)89484-X. PMID 8207021.
  5. ^ Shashidharan P, Clarke DD, Ahmed N, Moschonas N, Plaitakis A (May 1997). "Nerve tissue-specific human glutamate dehydrogenase that is thermolabile and highly regulated by ADP". J. Neurochem. 68 (5): 1804–11. doi:10.1046/j.1471-4159.1997.68051804.x. PMID 9109504. S2CID 83848260.

Further reading

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